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Pharmacology

The use of chemical treatments has become the norm today. At the same time, the effect of drugs on the human body is quite ambiguous: on the one hand, they cure the disease, but at the same time, we get a number of side effects. That is why our team has focused on the production and use of bioorganic and nanomaterials in medicine. The advantages of such medicines are their precise effect on the cells affected by the disease without negative consequences for other organs. Therefore, we invest and raise funding in the development of new types of human-friendly medicines.

  1. Utility model patent No. 66481 Ukraine, IPC (2011.01) C07D 417/00, A61K 31/425 (2006.01), A61K 31/429 (2006.01). 2,5,7-Substituted derivatives of [1,3]thiazolo[4,5-D]pyridazin-4(5H)-ones with antitumor activity // Demchenko S.A., Bobkova L.S., Demchenko A.M. – № u 201106079; Application for utility patent for Ukraine filed on May 16, 2011; Published on January 10, 2012, Bulletin No. 1.
  1. Utility model patent No. 83239 Ukraine, IPC (2013.01) C07D 417/00 A61K 31/425 (2006.01). 2-(4,5-Diphenyl-4H-[1,2,4]triazol-3-yl-sulfanyl)-N-aryl acetamides with antitumor activity // Demchenko A.M., Sukhoveyev V.V., Georgiyants V.A., Saidov N.B., Kadamov I.M., Grinevich O.Y. – No. u 2013 04229; Application for application for a patent for a new biologically active substance; Published on 27.08.2013, Bulletin No. 16.
  1. Utility model patent No. 84238 Ukraine, IPC C07D 487/04 (2006.01). Imidazole hydrochloride 3-(31,51-ditrobutyl-41-hydroxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole with antitumor properties // Demchenko A.M., Sukhoveev V.V., Moskalenko O.V., Hrynevych O.Y. – No. u 2013 05748; Application for application for patent for Ukraine filed on May 07, 2013; Published on October 10, 2013, Bulletin No. 19.
  1. Patent for invention No. 89504 Ukraine, IPC (2009), C01B 7/00, C07D 473/04 (2006.01), A61K 31/52 (2006.01), A61K 31/755 (2006.01). Adduct of 5-fluorouracil and sodium salt of diphenyl phosphoric acid for the treatment of cancer // Stefanov O.V., Sharykina N.I., Demchenko A.M., Kudriavtseva I.G., Khavych O.O., Titarenko I.P., Bobkova L.S., Sergeev V.S., Golubov M.I., Sergienko O.V. – No. a 2007 03652; Application for application for a patent for a new method of treatment of cancer.
  1. Utility model patent No. 89528 Ukraine, IPC C07D 417/00 A61P 35/00. Hydrobromides of 3-aryl-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazine compounds with antitumor activity // Demchenko A.M., Yanchenko V.O., Sukhoveev V.V., Grinevich O.Y. – No. u 2013 13198; Application for application for 2013-11-13. Published on April 25, 2014, Bulletin No. 8.
  1. Utility model patent No. 89761 Ukraine, IPC C07D 417/00 A61P 35/00. Hydrobromides of 3-alkyl-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazine compounds with antitumor activity // Demchenko A.M., Yanchenko V.O., Sukhoveev V.V., Grinevich O.Y. – No. u 2013 14827; Application for application for Ukraine on December 18, 2013. Published on 25.04.2014, Bulletin No. 8.
  1. Utility model patent No. 94833 Ukraine, IPC (2014.01) C07D 417/00 A61R 35/00. Substituted 7-(benzylthio)-3-tert-butyl-4H-[1,3,4]thiadiazolo[2,3-c] [1,2,4]triazine-4-ones with antitumor activity // Demchenko A.M., Yanchenko V.O., Akimenko A.O., Sukhoveev V.V. – No. u 2014 03356; Application for application for patent for Ukraine filed on April 02, 2014; Published on December 10, 2014, Bulletin No. 23.
  1. Patent for invention No. 107517 Ukraine, IPC C07D 487/04 (2006.01). Imidazole hydrochloride 3-(31,51-ditrobutyl-41-hydroxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole with antitumor properties // Demchenko A.M., Sukhoveev V.V., Moskalenko O.V., Hrynevych O.Y. – No. A 2013 05746; Application for application for patent for Ukraine filed on May 07, 2013; Published on January 12, 2015, Bulletin No. 1.
  1. Patent for invention No. 109814 Ukraine, IPC C07D 417/00 A61P 35/00. Hydrobromides of 3-aryl-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo [3,4-b][1,3,4] thiadiazine with antitumor activity // Demchenko A.M., Yanchenko V.O., Sukhoveev V.V., Grinevich O.Y. – No. u 2013 13197; Application for application for patent for Ukraine No. 131197. Published on 12.10.2015, Bulletin No. 19.
  1. Patent for invention No. 111432 Ukraine, IPC (2016.01) A61K31/517 (2006.01), A61Z 35/00. 2-(3-Allyl-4-oxo-3,4-dihydroquinazolin-2-yl-sulfanyl)- N-(2,3-dichlorophenyl)-acetamide with antitumor effect // Sharykina N.I, Demchenko A.M., Bobkova L.S., Meshkova N.O., Kelsh Y.P., Mishchenko O.V. – No. a 2015 00282; ; Application for application for a patent for a new compound for the treatment of tumors.
  1. Utility model patent No. 116314 Ukraine, IPC (2017.01) C07D 487/04 (2006.01), A61P35/00. Hydrochloride of 2,6-Ditrobutyl-4-(6,7,8,9-tetrahydro-5H-imidazo[1,2-а]azepin-3-yl)phenol with antitumor properties // Demchenko S.A., Bobkova L.S., Demchenko A.M. – No. u 2016 13047; Application for application for patent for Ukraine on 21.14.2016; Published on 10.05.2017, Bulletin No. 9.
  1. Utility model patent No. 116804 Ukraine, IPC (2017.01) C07D 417/00. (2,3-Dihydrobenzo[1,4]dioxan-6-yl)-(3-phenyl-7H-[1,2,4]-triazolo)- [3,4-b][1,3,4]thiadiazin-6-yl) amine with antitumor activity // Demchenko A.M., Yanchenko V.O., Koval A.Y., Demenko D.A., Bobkova L.S. – No. u 2016 11805; Application for application for a patent for a new antitumor agent for the treatment of cancer.
  1. Utility model patent No. 116873 Ukraine, IPC (2017.01) C07D 417/00. 2-[4-Benzyl-5-(4′-bromophenoxymethyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-arylacetamides with antitumor activity // Demchenko A.M., Yanchenko V.O., Saidov N.B., Georgiyants V.A., Bobkova L.S. – No. u 2016 12402; Application for application for patent for Ukraine filed on December 06, 2016; Published on June 12, 2017, Bulletin No. 11.
  1. Utility model patent No116901 Ukraine, IPC (2017.01) C07D 417/00. 2-[5-(2-Isopropyl-5-methylphenoxymethyl)-4-phenyl-4H-[1,2,4]triazol-3-yl-sulfanyl]-1-arylethanones with antitumor properties // Demchenko A.M., Dudnik A.E., Saidov N.B., Georgiyants V.A., Bobkova L.S. – No. u 2016 12799; Application for application for patent for Ukraine filed on December 15, 2016; Published on June 12, 2017, Bulletin No. 11.
  1. Utility model patent No. 116952 Ukraine, IPC (2017.01) C07D 417/00. 5,7-Diacyl-3-ethyl(cyclohexyl)-6-(4-chloro-3R-phenyl)-5H-[1,2,4]-triazolo) [3,4-b][1,3,4]Thiadiazines with antitumor activity // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. u 2016 13256; Application for application filed on December 26, 2016; Published on June 12, 2017, Bulletin No. 11.
  1. Utility model patent No. 117204 Ukraine, IPC (2017.01) C07D 253/065 (2006.01), C07D 295/00. N-(3,4-Dimethylphenyl)-6-morpholin-4-yl-N’-(3′-trifluoromethylphenyl)-[1,3,5]triazine-2,4-diamine with antitumor properties // Demchenko A.M., Sukhoveev V.V., Barchina O.I., Bobkova L.S. – No. u 2016 11883; Application for application for patent for Ukraine filed on November 24, 2016; Published on June 26, 2017, Bulletin No. 12.
  1. Utility model patent No. 117205 Ukraine, IPC (2017.01) C07D -417/00. 7-Phenyl-2-(1H-pyrrole-1-yl)-5H-thiazolo[4,5-d]pyridazin-4-one with antitumor properties // Demchenko S.A., Sukhoveev V.V., Bobkova L.S., Demchenko A.M. – No. u 2016 11885; Application for application for utility patent for Ukraine filed on November 24, 2016; Published on June 26, 2017, Bulletin No. 12.
  1. Utility model patent No. 117266 Ukraine, IPC (2017.01) C07D 253/065 (2006.01), C07D 295/00. 3-(2′,4′-Dichlorophenoxymethyl)-6-(4”-methoxy(or 4”-difluoromethoxyphenyl)-7H-[1,2,4]triazolo[3,4b]thiadiazines with antitumor properties // Demchenko A.M., Sukhoveev V.V., Demchenko D.A., Yanchenko V.O., Bobkova L.S. – No. u 2016 13001; Application for application for a patent for a new biological agent for the treatment of tumors.
  1. Utility model patent No. 117495 Ukraine, IPC (2017.01) C07D 417/00, A61P 35/00. 5,7-Dipropionyl-3-(4′-methoxybenzyl)-6-(4”-methoxyphenyl)-5H-[1,2,4]triazolo [4,3-b][1,3,4]Thiadiazine with antitumor activity // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. u 2017 00865; Application for application filed on January 31, 2017; Published on June 26, 2017, Bulletin No. 12.
  1. Utility model patent No. 117496 Ukraine, IPC (2017.01) C07D 417/00, A61K 31/425 (2006.01). 2-[5-(4-R-phenyl)-4-(meta-tolyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-arylacetamides with antitumor properties // Demchenko A.M. – No. u 2017 00866; Application for application filed on January 31, 2017; Published on June 26, 2017, Bulletin No. 12.
  1. Utility model patent No. 117497 Ukraine, IPC (2017.01) C07D 487/04, A61P 35/00. Bromide of 3-hydroxy-1,3-bis(4′-methoxyphenyl)-2,3,5,6,7,8-hexahydroimidazo[1,2-а]pyridinium with antitumor properties // Demchenko S.A., Sukhoveev O.V., Demchenko A.M., Bobkova L.S. – No. u 2017 00868; Application for application filed on January 31, 2017; Published on June 26, 2017, Bulletin No. 12.
  1. Utility model patent No. 117545 Ukraine, IPC (2017.01) C07D 487/00, A61P 35/00. 1-Phenyl-4-aryl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[c,d]azulenes with antitumor activity // Demchenko S.A., Kolesnikov O.V., Demchenko A.M., Bobkova L.S. – No. u 2017 01123; Application for application for patent for Ukraine filed on February 07, 2017; Published on June 26, 2017, Bulletin No. 12.
  1. Utility model patent No. 118179 Ukraine, IPC (2017.01) C07D 417/00. 5,7-Dipropionyl-6-(4′-cyclohexylphenyl)-5H-[1,2,4]triazolo [4,3-b][1,3,4]Thiadiazine with antitumor properties // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. u 2017 01375; Application for application filed on February 14, 2017; Published on July 25, 2017, Bulletin No. 14.
  1. Utility model patent No. 118189 Ukraine, IPC (2017.01) C07D 417/00. 3-(4′-methoxyphenyl)-6(4”-fluorophenyl-5,7-di-R-acyl-5H-[1,2,4]-triazolo [3,4-b][1,3,4] thiadiazines with antitumor properties, in particular, in relation to intestinal cancer cell lines // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. u 2017 01466; Application for application filed on February 16, 2017; Published on July 25, 2017, Bulletin No. 14.
  1. Utility model patent No. 118234 Ukraine, IPC (2017.01) C07D 417/00. 1-(2-Iso-propyl-5-methylphenoxymethyl)-3R-4-aryl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulenes with antitumor activity // Demchenko S.A, Dudnyk A.E., Bukhtiarova T.A., Demchenko A.M., Bobkova L.S. – No. u 2017 02036; Application for application for a patent for a new compound of azulenes with antitumor activity.
  1. Utility model patent No. 118683 Ukraine, IPC (2017.01) C07D 417/00. 6-(4-ethoxyphenyl)-3-(para-tolyl)-7H-[1,2,4]-triazolo [3,4-b][1,3,4]Thiadiazine with antitumor properties // Demchenko A.M., Sukhoveev V.V., Demchenko D.A., Bobkova L.S. – No. u 2017 00316; Application for application filed on January 12, 2017; Published on August 28, 2017, Bulletin No. 16.
  1. Utility model patent No. 118861 Ukraine, IPC (2017.01) C07D 487/00. 5-Benzyl-7-(furan-2-yl)-2-piperidin-1-yl-5H-thiazolo[4,5-d]-pyridazinone-4 with antitumor properties // Demchenko A.M., Sukhoveev V.V., Demchenko S.A., Sukhoveev O.V., Bobkova L.S. – No. u 2017 02991; Application for application for patent for Ukraine filed on March 30, 2017; Published on August 28, 2017, Bulletin No. 16.
  1. Utility model patent No. 120100 Ukraine, IPC (2017.01) C07D 487/00, A 61P 35/00. 4-Aryl-1-phenoxymethyl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulenes with antitumor activity // Demchenko S.A., Volochniuk D.M., Demchenko A.M., Bobkova L.S. – No. u 2017 03603; Application for application filed on April 13, 2017; Published on October 25, 2017, Bulletin No. 20.
  1. Utility model patent No. 121195 Ukraine, IPC (2017.01) C07D 487/04, A61K 31//00, A 61P 35/00. Hydrobromide of 1-(41-cyclohexylphenyl)-2-[5,6-dihydro-4H-[1,3]thiazin-2-yl)-(42-ethylphenyl)amino]ethanone with antitumor properties // Demchenko S.A., Volochniuk D.M., Bobkova L.S., Demchenko A.M. – No. u 2017 06316; Application for application for patent for Ukraine (in Ukrainian); Published on June 21, 2017; Published on November 27, 2017, Bulletin No. 22.
  1. Utility model patent No. 121779 Ukraine, IPC (2006) C07D 487/00, A 61P 35/00. 1-(21-Methoxyphenyl)aminomethyl-4-phenyl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd] azulene with antitumor activity // Demchenko S.A., Bobkova L.S., Bukhtiarova T.A., Demchenko A.M. – No. u 2017 07644; Application for application filed on July 19, 2017; Published on December 11, 2017, Bulletin No. 23.
  1. Patent for invention No. 115644 Ukraine, IPC (2006): C07D 249/12 (2006.01), A61R 35/00. 2-[5-(4-R-phenyl)-4-(meta-tolyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-arylacetamides with antitumor properties // Demchenko A.M. – No. a 2017 00867; Application for application for patent for Ukraine filed on January 31, 2017; Published on November 27, 2017, Bulletin No. 22.
  1. Patent for invention No. 115749 Ukraine, IPC (2006): С07D 471/04 (2006.01), С07D 487/04 (2006.01), А61Р 35/00. Pyridinium bromide 3-hydroxy-1,3-bis(4′-methoxyphenyl)-2,3,5,6,7,8-hexahydroimidazo[1,2-а]pyridinium with antitumor properties // Demchenko S.A., Sukhoveiev O.V., Demchenko A.M., Bobkova L.S. – No. u 2017 00869; Application for application filed on January 31, 2017; Published on December 11, 2017, Bulletin No. 23.
  1. Patent for invention No. 115750 Ukraine, IPC (2006): С07D 487/06 (2006.01), А61К 31/343 (2006.01), А61Р 35/00, С07С 13/52 (2006.01). 1-Phenyl-4-aryl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[c,d]azulenes with antitumor activity // Demchenko S.A., Kolesnikov O.V., Demchenko A.M., Bobkova L.S. – No. a 2017 01124; Application for application for a patent for a new antitumor agent for the treatment of cancer.
  1. Utility model patent No. 123593 Ukraine, IPC (2018.01) C07D 417/00, A61K 31/425 (2006.01), A61K 31/429 (2006.01), A61P 35/04 (2006.01). 2-(7-Furan-21-yl-2-morpholin-41-yl-4-oxo-4H-thiazolo[4,5-d]pyridazin-5-yl)-N-naphthalene-1-yl-acetamide with antitumor activity // Demchenko A.M., Yarmolyuk S.M., Sharykina N.I., Bobkova L.S., Demchenko S.A., Kukharenko O.P. – No. u 2017 11183; Application for application filed on November 15, 2017; Published on February 26, 2018, Bulletin No. 4.
  1. Patent for invention No. 116424 Ukraine, IPC (2006) C07D 417/04 (2006.01), A61R 35/00, C07D 513/04 (2006.01), A61K 31/33 (2006.01). 5,7-Dipropionyl-3-(4′-methoxybenzyl)-6-(4”-methoxyphenyl)-5H-[1,2,4]triazolo [4,3-b][1,3,4]thiadiazine with antitumor activity // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. a 2017 00864; Application for application filed on January 31, 2017; Published on March 12, 2018, Bulletin No. 5.
  1. Patent for invention No. 116426 Ukraine, IPC (2006) C07D 417/04, A61K 31/33 (2006.01), A61R 35/00, C07D 513/04 (2006.01). 3-(4′-methoxyphenyl)-6(4”-fluorophenyl-5,7-di-R-acyl-5H-[1,2,4]-triazolo [3,4-b][1,3,4] thiadiazines with antitumor properties, in particular, in relation to intestinal cancer cell lines // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. a 2017 01465; Application for patent for the invention of thiadiazines, filed on February 16, 2017; Published on March 12, 2018, Bulletin No. 5.
  1. Patent for invention No. 116947 Ukraine, IPC (2006) C07D 513/04 (2006.01), A61K 31/549 (2006.01), A61R 35/00. 5,7-Diacyl-3-ethyl(cyclohexyl)-6-(4-chloro-3R-phenyl)-5H-[1,2,4]-triazolo [3,4-b][1,3,4] thiadiazines with antitumor properties // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. a 2016 13255; Application for application filed on December 26, 2016; Published on May 25, 2018, Bulletin No. 10.
  1. Utility model patent No. 123896 Ukraine, IPC (2006) C07D 487/00, A61P 35/00. 1-(41-Bromophenyl)-4-aryl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulenes with antitumor activity // Demchenko S.A., Artemchuk L.P., Demchenko A.M., Bobkova L.S. – No. u 2017 09889; Application for application filed on October 12, 2017; Published on March 12, 2018, Bulletin No. 5.
  1. Patent for invention No. 117404 Ukraine, IPC (2006) C07D 417/12 (2006.01), C07D 285/16 (2006.01), C07D 249/08 (2006.01), C07D 513/04 (2006.01), C07D 319/18 (2006.01), A61K 31/33 (2006.01), A61P 35/00 (2006.01). (2,3-Dihydrobenzo[1,4]dioxan-6-yl)-(3-phenyl-7H-[1,2,4]-triazolo)- [3,4-b][1,3,4]thiadiazin-6-yl) amine with antitumor activity // Demchenko A.M., Yanchenko V.O., Koval A.Y., Demchenko D.A., Bobkova L.S. – No. a 2016 11804; Application for application for a patent for a new antitumor agent for the treatment of cancer.
  1. Patent for invention No. 117406 Ukraine, IPC (2006) C07D 487/04 (2006.01), A61P35/00, A61K31/4184. Hydrochloride of 2,6-Ditrobutyl-4-(6,7,8,9-tetrahydro-5H-imidazo[1,2-а]azepin-3-yl)phenol with antitumor properties // Demchenko S.A., Bobkova L.S., Demchenko A.M. – No. a 2016 13046; Application for application for patent for Ukraine (2016), Dec. 21, 2016; Published on July 25, 2018, Bulletin No. 18.
  1. Utility model patent No. 128071 Ukraine, IPC (2006) A61K 31/381, A61K 31/498, C07D 409/12, A61P 35/00.// Ethyl-2-(quinazolin-4-yl-amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate hydrochloride with antitumor activity in non-small cell lung cancer of humans, Demchenko A.M., Meshkova N.O., Bobkova L.S., Khairulin A.R., Mishchenko O.V., Rogozin V.V., Cherviovskyi D.O., Pendeliuk S.I., Maksiuta S.I., Bukhtiarova T.A. – № u 201804303; Application for application filed on April 19, 2018; Published on August 27, 2018, Bulletin No. 16.
  1. Utility model patent No. 129434 Ukraine, IPC (2006) A61P 35/00, C07D 417/00. 1-[6-(41-Етилфеніл)-3-метил-5-пропіоніл-5Н-[1,2,4]триазоло [3,4-b][1,3,4]thiadiazin-7-yl]-propan-1-one with antitumor properties // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. u 2018 05732; Application for application for the patent for Ukraine No. 2018 05732; Published on October 25, 2018, Bulletin No. 20.
  1. Patent for invention No. 118703 Ukraine, IPC (2006) C07D 417/00, A61R 35/00. 6-(4-ethoxyphenyl)-3-(para-tolyl)-7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazine with antitumor properties // Demchenko A.M., Sukhoveev O.V., Demchenko D.A., Bobkova L.S. – No. a 2017 00318; Application for application filed on January 12, 2017; Published on February 25, 2019, Bulletin No. 4/2019.
  1. Patent for invention No. 118873 Ukraine, IPC (2006) C07D 417/00, A61K 31/425 (2006.01).//7-Phenyl-2-(1H-pyrrole-1-yl)-5H-thiazolo[4,5-d]pyridazin-4-one with antitumor properties // Demchenko S.A., Sukhoveev V.V., Bobkova L.S., Demchenko A.M. – No. a 2016 11886; Application for application on November 24, 2016; Published on March 25, 2019, Bulletin No. 6/2019.
  1. Patent for invention No. 119172 Ukraine, IPC (2017.01) C07D 249/08 (2006.01), C07D 285/16 (2006.01), C07D 417/04 (2006.01), C07D 514/04 (2006.01), A61K 31/33 (2006.01), A61R 35/00 (2006.01).// 3-(21,41-Dichlorophenoxymethyl)-6-(41-methoxy- or 41-difluoromethoxyphenyl)-7H-[1,2,4]triazolo[3,4b][1,3,4]thiadiazines with antitumor properties // Demchenko A.M, Sukhoveev V.V., Demchenko D.A., Yanchenko V.O., Bobkova L.S. – No. u 2016 12999; Application for application for a patent for a new type of thiadiazine; Declared on December 20, 2016; Published on May 10, 2019, Bulletin No. 9/2019.
  1. Patent for invention No. 119468 Ukraine, IPC (2006) C07D 255/04, A61R 35/00, A61K 31/33, A61K 31/423, C07D 249/16. Application of 1-(2-Iso-propyl-5-methylphenoxymethyl)-3R-4-aryl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopentane[cd]azulenes as compounds with antitumor activity // Demchenko S.A., Дудник А.Є., Бухтіарова Т.А., Демченко А.М., Бобкова Л.С. – № а 2017 02037; Заявл. 02.03.2017; Опубл. 25.06.2019, Бюл. № 12.
  1. Utility model patent No. 135600 Ukraine, IPC (2006) C07D 487/00, A61P 35/00, A61K 31/00.//3-R-Phenylamides of 1-(41-isopropylphenyl)-4-(42-chlorophenyl)-5,6,7,8-tetrahydro-2,4a-diazacyclopentane[c,d]azulen-2-carboxylic acid with antitumor activity against PC-3 prostate cancer cells // Demchenko S.A, Fedchenkova Y.A., Sukhoveiev V.V., Demchenko A.M. – No. u 2019 00533; Application for application on January 23, 2019; Published on July 10, 2019, Bulletin No. 13/2019.
  1. Patent for invention No. 120051 Ukraine, IPC (2017.01) C07D 251/54 (2006.01), C07D 295/00 (2006.01), A 61K 31/53 (2006.01), A 61K 31/5375 (2006.01), A 61P 35/00. The use of N-(3,4-Dimethylphenyl)-6-morpholin-4-yl-N’-(3′-trifluoromethylphenyl)-[1,3,5]triazine-2,4-diamine as an antitumor agent for the treatment of breast cancer of the MDA-MB-468 subtype // Demchenko A.M, Sukhoveiev V.V., Barchina O.I., Bobkova L.S. – No. a 2016 11884; Application for application on November 24, 2016; Published on September 25, 2019, Bulletin No. 18|2019.
  1. Utility model patent No. 136968 Ukraine, IPC (2006) C07D 487/00, A61P 35/00. [4-(41-Chlorophenyl)-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulen-1-yl-methyl]-para-tolylamine, which has antitumor activity against cancer cell lines of leukemia // Demchenko S.A, Sukhoveiev V.V., Shvydko O.V., Demchenko A.M. – No. u 2019 01414; Application for application on February 12, 2019; Published on September 25, 2019, Bulletin No. 18/2019.
  1. Patent for invention No. 120182 Ukraine, IPC (2006) C07D 487/04 (2006.01), C07D 255/04 (2006.01), C07D 249/16 (2006.01), A 61K 31/33 (2006.01), A 61K 31/423 (2006.01). The use of 4-aryl-1-phenoxymethyl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopentane[cd]azulenes as compounds with antitumor activity // Demchenko S.A., Volochniuk D.M., Demchenko A.M., Bobkova L.S. – No. a 2017 03602; Application for application for a patent for Ukraine for a new antitumor agent for the treatment of cancer.
  1. Utility model patent No. 139230 Ukraine, IPC (2006) A 61K 31/5517 (2006.01), C07 D 487/04 (2006.01), C07 D 223/26 (2006.01), A 61 P 35/00. // Bromide 1-(41-methoxyphenyl)-3-(42-biphenyl)-3-hydroxy-2,5,6,7,8,8-hexahydro-3H-imidazo[1,2-а]azepinium with antitumor properties // Demchenko S.A, Fedchenkova Y.A., Sukhoveiev V.V., Demchenko A.M. – No. u 2019 06623; Application for application on June 13, 2019; Published on December 26, 2019, Bulletin No. 24/2019.
  1. Patent for invention No. 120939 Ukraine, IPC (2006) C07D 417/00, A61P 35/00, C07D 513/04 (2006.01), C07D 285/16 (2006.01), C07D 249/08 (2006.01), A61K 31/33 (2006.01). Application of 5,7-dipropionyl-6-(4′-cyclohexylphenyl)-5H-[1,2,4]triazolo [4,3-b][1,3,4]of thiadiazine as a compound with antitumor properties // Demchenko A.M., Yanchenko V.O., Demchenko D.A., Bobkova L.S. – No. a 2017 01374; Application for application for a patent for Ukraine on February 14, 2017; Published on March 10, 2020, Bulletin No. 5/20.
  1. Patent for invention No. 121172 Ukraine, IPC (2006) C07D 487/06, A61K 31/395, A61R 35/00.//3-R-Phenylamides of 1-(41-isopropylphenyl)-4-(42-chlorophenyl)-5,6,7,8-tetrahydro-2,4a-diazacyclopentane[c,d]azulen-2-carboxylic acid with antitumor activity against PC-3 prostate cancer cells // Demchenko S.A, Fedchenkova Y.A., Sukhoveiev V.V., Demchenko A.M. – No. a 2019 00686; Application for application on January 23, 2019; Published on April 10, 2020, Bulletin No. 7/2020.
  1. Patent for invention No. 121227 Ukraine, IPC (2017.01) C07D 279/06, A61K 31//54, A 61P 35/00. Application of hydrobromide 1-(41-cyclohexylphenyl)-2-[5,6-dihydro-4H-[1,3]thiazin-2-yl)-(42-ethylphenyl)amino]ethanone as a compound with antitumor properties // Demchenko S.A., Volochniuk D.M., Bobkova L.S., Demchenko A.M. – No. a 2017 06315; Application for application for a patent for a new product; Published on April 27, 2020, Bulletin No. 8/2020.
  1. Patent for invention No. 121900 Ukraine, IPC (2006) A61K 31/381, A61K 31/498, C07D 409/12, A61P 35/00. Ethyl-2-(quinazolin-4-ylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate hydrochloride with antitumor activity in human non-small cell lung cancer // Sharykina N.I, Demchenko A.M., Meshkova N.O., Bobkova L.S., Khairulin A.R., Mishchenko O.V., Rogozin V.V., Cherviovskyi D.O., Pendelu S.I., Maksiuta S.V., Bukhtiarova T.A.- No. a 201804302; Application for application submitted on April 19, 2018; Published on August 10, 2020, Bulletin No. 15/2020.
  1. Patent for invention No. 123601 Ukraine, IPC (2006) C07D 487/16, A61P 35/00, A61K 31/55 Application of [4-(41-Chlorophenyl)-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopentane[cd]azulen-1-yl-methyl]-para-tolylamine as an active substance with selective antitumor activity against cancer cell lines CCRF-CEM.// Demchenko SA, Sukhoveiev V.V., Shvydko O.V., Demchenko A.M. – No. a 2019 01413; Application for application on February 12, 2019; Published on April 28, 2021, Bulletin No. 17/2021.
  1. Patent for invention No. 123969 Ukraine, IPC (2006) C07D 487/04, A61K 31/55, A61P 31/00 // Bromide of 1-(41-methoxyphenyl)-3-(42-biphenyl)-3-hydroxy-2,5,6,7,8,9-hexahydro-3H-imidazo[1,2-a]azepinium with antitumor properties // Demchenko S.A., Fedchenkova Y.A., Sukhoveiev V.V., Demchenko A.M. – No. u 2019 06624; Application for application on June 13, 2019; Published on July 01, 2021, Bulletin No. 26/2021.

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